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Article

Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria.

Malaria journal - 7 Jan 2016

Shah Shivang S, Rockett Kirk A, Jallow Muminatou, Sisay-Joof Fatou, Bojang Kalifa A, Pinder Margaret, Jeffreys Anna, Craik Rachel, Hubbart Christina, Wellems Thomas E, Kwiatkowski Dominic P

Abstract excerpt

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency exhibits considerable allelic heterogeneity which manifests with variable biochemical and clinical penetrance. It has long been thought that G6PD deficiency confers partial protection against severe malaria, however prior genetic association studies have disagreed with regard to the strength and specificity of a protective effect, which might reflect...

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Identifiers

PMID: 26738565
DOI: 10.1186/s12936-015-1045-0
PMCID: PMC4704392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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