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Article

Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment.

Nature communications - 10 Jul 2024

Levine Adrian B, Nobre Liana, Das Anirban, Milos Scott, Bianchi Vanessa, Johnson Monique, Fernandez Nicholas R, Stengs Lucie, Ryall Scott, Ku Michelle, Rana Mansuba, Laxer Benjamin, Sheth Javal, Sbergio Stefanie-Grace, Fedoráková Ivana, Ramaswamy Vijay, Bennett Julie, Siddaway Robert, Tabori Uri, Hawkins Cynthia

Abstract excerpt

With the success of immunotherapy in cancer, understanding the tumor immune microenvironment (TIME) has become increasingly important; however in pediatric brain tumors this remains poorly characterized. Accordingly, we developed a clinical immune-oncology gene expression assay and used it to profile a diverse range of 1382 samples with detailed clinical and molecular annotation. In low-grade gliomas we identify...

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Source

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Identifiers

PMID: 38987542
DOI: 10.1038/s41467-024-49595-1
PMCID: PMC11237052

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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