Article
Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity.
Nature communications - 28 Aug 2020
Grabovska Yura, Mackay Alan, O'Hare Patricia, Crosier Stephen, Finetti Martina, Schwalbe Edward C, Pickles Jessica C, Fairchild Amy R, Avery Aimee, Cockle Julia, Hill Rebecca, Lindsey Janet, Hicks Debbie, Kristiansen Mark, Chalker Jane, Anderson John, Hargrave Darren, Jacques Thomas S, Straathof Karin, Bailey Simon, Jones Chris, Clifford Steven C, Williamson Daniel
Abstract excerpt
Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency of the Tumor Immune Microenvironment (TIME) likely to predict patient response. Here, we describe the TIME of >6000 primarily pediatric CNS tumors using a deconvolution approach (methylCIBERSORT). We produce and validate a custom reference signature defining 11 non-cancer cell...
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