Article
Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia.
Communications biology - 31 Mar 2023
Cheng Chi-Keung, Yung Yuk-Lin, Chan Hoi-Yun, Leung Kam-Tong, Chan Kathy Y Y, Leung Alex W K, Cheng Frankie W T, Li Chi-Kong, Wan Thomas S K, Luo Xi, Pitts Herbert-Augustus, Cheung Joyce S, Chan Natalie P H, Ng Margaret H L
Abstract excerpt
Pediatric acute myeloid leukemia (AML) is an uncommon but aggressive hematological malignancy. The poor outcome is attributed to inadequate prognostic classification and limited treatment options. A thorough understanding on the genetic basis of pediatric AML is important for the development of effective approaches to improve outcomes. Here, by comprehensively profiling fusion genes as well as mutations and copy...
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