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Article

Somatic characterization of pediatric acute myeloid leukemia using next-generation sequencing.

Seminars in hematology - 1 Oct 2013

Schuback Heather L, Arceci Robert J, Meshinchi Soheil

Abstract excerpt

Acute myeloid leukemia (AML) is a complex and heterogeneous disease with distinct age-associated genomic and epigenomic alterations. A large number of somatic karyotypic and molecular alterations have been identified in AML to date; however, very few predict outcome or identify potential therapeutic targets. Here we describe the current state of known molecular and genetic alterations in pediatric AML. Further,...

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PMID: 24246700
DOI: 10.1053/j.seminhematol.2013.09.003

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