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Article

Novel classification system and high-risk categories of pediatric acute myeloid leukemia.

Haematologica - 1 Sept 2025

Umeda Masayuki, Liu Yen-Chun, Karol Seth E, Klco Jeffery M

Abstract excerpt

The prognosis of pediatric acute myeloid leukemia (AML) remains poor compared with pediatric acute lymphoblastic leukemia (ALL); accurate diagnosis and treatment strategies based on the genomic background are urgently needed. Recent advances in sequencing technologies have identified novel pediatric AML subtypes, including BCL11B structural variants and UBTF tandem duplications (UBTF-TD), associated with poor...

Read the complete abstract on PubMed

Topics

Humans
Leukemia, Myeloid, Acute
Child
Prognosis
Biomarkers, Tumor
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 39781610
DOI: 10.3324/haematol.2024.285644
PMCID: PMC12399961

Genes

BCL11B
CBFA2T3
GLIS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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