Article
Uncommon cytogenetic abnormalities identifying high-risk acute myeloid leukemia in children.
Future oncology (London, England) - 1 Nov 2020
Masetti Riccardo, Bertuccio Salvatore Nicola, Guidi Vanessa, Cerasi Sara, Lonetti Annalisa, Pession Andrea
Abstract excerpt
Pediatric acute myeloid leukemia (AML) represents an aggressive disease and is the leading cause of childhood leukemic mortality. The genomic landscape of pediatric AML has been recently mapped and redefined thanks to large-scale sequencing efforts. Today, understanding how to incorporate the growing list of genetic lesions into a risk stratification algorithm for pediatric AML is increasingly challenging given...
Topics
- Age Factors
- Child
- Chromosome Aberrations
- Disease Management
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Leukemia, Myeloid, Acute
- Molecular Targeted Therapy
- Prognosis