Article
Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating.
The Journal of biological chemistry - 24 Nov 2006
Lampert Angelika, Dib-Hajj Sulayman D, Tyrrell Lynda, Waxman Stephen G
Abstract excerpt
The Nav1.7 sodium channel is preferentially expressed in most nociceptive dorsal root ganglion neurons and in sympathetic neurons. Inherited erythromelalgia (IEM, also known as erythermalgia), an autosomal dominant neuropathy characterized by burning pain in the extremities in response to mild wa...
Topics
- Action Potentials
- Cell Line
- Erythromelalgia
- Genes, Dominant
- Humans
- Ion Channel Gating
- Membrane Potentials
- Models, Chemical
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- Patch-Clamp Techniques
- Serine
- Sodium Channels
- Threonine
- Transfection