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Article

The S4---S5 linker - gearbox of TRP channel gating.

Cell calcium - 1 Nov 2017

Hofmann Laura, Wang Hongmei, Zheng Wang, Philipp Stephan E, Hidalgo Patricia, Cavalié Adolfo, Chen Xing-Zhen, Beck Andreas, Flockerzi Veit

Abstract excerpt

Transient receptor potential (TRP) channels are cation channels which participate in a wide variety of physiological processes in organisms ranging from fungi to humans. They fulfill roles in body homeostasis, are sensors for noxious chemicals and temperature in the mammalian somatosensory system and are activated by light stimulated phospholipase C activity in Drosophila or by hypertonicity in yeast. The...

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Source

Identifiers

PMID: 28416203
DOI: 10.1016/j.ceca.2017.04.002

Genes

TRPA1
TRPV1
TRPV2
TRPV6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The S4---S5 linker - gearbox of TRP channel gating.PMID 28416203Read ↗

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels.Semantic proximity Read ↗

A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.Semantic proximity Read ↗

L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.Semantic proximity Read ↗

A conserved gating element in TRPV6 channels.Semantic proximity Read ↗

The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.Semantic proximity Read ↗

Cytoplasmic inter-subunit interface modulates TRPC5 activity: Molecular mechanism behind intellectual disability-related R175C mutation.Semantic proximity Read ↗

The TRP channel superfamily: insights into how structure, protein-lipid interactions and localization influence function.Semantic proximity Read ↗

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Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels.Semantic proximity Read ↗

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