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Article

L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015

Teng Jinfeng, Loukin Stephen H, Anishkin Andriy, Kung Ching

Abstract excerpt

Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-turn amphipathic helix, and the invariant tryptophan forms a bond with the beginning of the...

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Identifiers

PMID: 25737550
DOI: 10.1073/pnas.1502366112
PMCID: PMC4371962

Genes

TRPV4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.PMID 25737550Read ↗

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