Article
Regulation and drug modulation of a voltage-gated sodium channel: Pivotal role of the S4-S5 linker in activation and slow inactivation.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jul 2021
Xiao Jinglei, Bondarenko Vasyl, Wang Yali, Suma Antonio, Wells Marta, Chen Qiang, Tillman Tommy, Luo Yan, Yu Buwei, Dailey William P, Eckenhoff Roderic, Tang Pei, Carnevale Vincenzo, Klein Michael L, Xu Yan
Abstract excerpt
Voltage-gated sodium (NaV) channels control excitable cell functions. While structural investigations have revealed conformation details of different functional states, the mechanisms of both activation and slow inactivation remain unclear. Here, we identify residue T140 in the S4-S5 linker of the bacterial voltage-gated sodium channel NaChBac as critical for channel activation and drug effects on inactivation....
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