Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISMERE Chromosome Engineering in Mouse and Rat.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Schaeffer Laurence, Lindner Loic, Pavlovic Guillaume, Hérault Yann, Birling Marie-Christine

Abstract excerpt

CRISPR/Cas9 technology is a versatile tool for engineering biology that has dramatically transformed our ability to manipulate genomes. In this protocol, we use its capacity to generate two double-strand breaks simultaneously, at precise positions in the genome, to generate mouse or rat lines with deletion, inversion, and duplication of a specific genomic segment. The technic is called CRISMERE for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes
Share to CRISPR-Cas Systems
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Genome

Share to Genomics

Source

Identifiers

PMID: 36995673
DOI: 10.1007/978-1-0716-2990-1_12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISMERE Chromosome Engineering in Mouse and Rat.PMID 36995673Read ↗

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERESemantic proximity Read ↗

Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.Semantic proximity Read ↗

Engineering new balancer chromosomes in C. elegans via CRISPR/Cas9.Semantic proximity Read ↗

A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research.Semantic proximity Read ↗

A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes.Semantic proximity Read ↗

CRISPR/Cas9 Genome Editing in Embryonic Stem Cells.Semantic proximity Read ↗

Creation of mutant mice with megabase-sized deletions containing custom-designed breakpoints by means of the CRISPR/Cas9 system.Semantic proximity Read ↗

An <i>in situ</i> cut-and-paste genome editing platform mediated by CRISPR/Cas9 or Cas12aSemantic proximity Read ↗

CRISPR/Cas9 Endonuclease-Mediated Mouse Genome Editing of One-Cell and/or Two-Cell Embryos by Electroporation, and the Use of Rad51 to Enhance Knock-In Allele Homozygosity via Interhomolog Repair Mechanism.Semantic proximity Read ↗

Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.Semantic proximity Read ↗

Randomizing the human genome by engineering recombination between repeat elementsSemantic proximity Read ↗

Engineering a mouse balancer chromosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.