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Article

A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes.

Genetics - 5 Jun 2024

Iwata Satoru, Nagahara Miki, Ido Risako, Iwamoto Takashi

Abstract excerpt

Complex chromosomal rearrangements (CCRs) are often observed in clinical samples from patients with cancer and congenital diseases but are difficult to induce experimentally. Here, we report the first success in establishing animal models for CCRs. Mutation in Recql5, a crucial member of the DNA helicase RecQ family involved in DNA replication, transcription, and repair, enabled CRISPR/Cas9-mediated CCRs,...

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Identifiers

PMID: 38577877
DOI: 10.1093/genetics/iyae054
PMCID: PMC11151919

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