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Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE

7 Mar 2017

Abstract excerpt

Modelling Down syndrome (DS) in mouse has been crucial for the understanding of the disease and the evaluation of therapeutic targets. Nevertheless, the modelling so far has been limited to the mouse and, even in this model, generating duplication of genomic regions has been labour intensive and time consuming. We developed the CRISpr MEdiated REarrangement (CRISMERE) strategy, which takes advantage of the...

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PMID: 28266534
DOI: 10.1038/srep43331

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