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Article

CRISPR/Cas9 Genome Editing in Embryonic Stem Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Andrey Guillaume, Spielmann Malte

Abstract excerpt

Targeted mutagenesis is required to evaluate the function of DNA segments across the genome. In recent years the CRISPR/Cas9 technology has been widely used for functional genome studies and is partially replacing classical homologous recombination methods in different aspects. CRISPR/Cas9-derived tools indeed allow the production of a wide-range of engineered mutations: from point mutations to large chromosomal...

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PMID: 27662879
DOI: 10.1007/978-1-4939-4035-6_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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