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Article

Engineering new balancer chromosomes in C. elegans via CRISPR/Cas9.

Scientific reports - 21 Sept 2016

Iwata Satoru, Yoshina Sawako, Suehiro Yuji, Hori Sayaka, Mitani Shohei

Abstract excerpt

Balancer chromosomes are convenient tools used to maintain lethal mutations in heterozygotes. We established a method for engineering new balancers in C. elegans by using the CRISPR/Cas9 system in a non-homologous end-joining mutant. Our studies will make it easier for researchers to maintain lethal mutations and should provide a path for the development of a system that generates rearrangements at specific sites...

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Identifiers

PMID: 27650892
DOI: 10.1038/srep33840
PMCID: PMC5030659

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