Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and Phenotypic Characterisations of Common Syngeneic Tumour Cell Lines as Estrogen Receptor-Positive Breast Cancer Models.

International journal of molecular sciences - 16 Mar 2023

Lambouras Maria, Roelofs Charlotte, Pereira Melrine, Gruber Emily, Vieusseux Jessica L, Lanteri Patrick, Johnstone Cameron N, Muntz Fenella, O'Toole Sandra, Ooms Lisa M, Mitchell Christina A, Anderson Robin L, Britt Kara L

Abstract excerpt

Estrogen receptor-positive breast cancers (ER+ BCas) are the most common form of BCa and are increasing in incidence, largely due to changes in reproductive practices in recent decades. Tamoxifen is prescribed as a component of standard-of-care endocrine therapy for the treatment and prevention of ER+ BCa. However, it is poorly tolerated, leading to low uptake of the drug in the preventative setting. Alternative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial Cells
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to Mice, 129 Strain

Share to Receptors, Estrogen

Share to RNA-Seq

Share to Tamoxifen

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 36982737
DOI: 10.3390/ijms24065666
PMCID: PMC10053941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and Phenotypic Characterisations of Common Syngeneic Tumour Cell Lines as Estrogen Receptor-Positive Breast Cancer Models.PMID 36982737Read ↗

Integrated molecular and functional profiling identifies E0771 as a basal-like triple-negative breast cancer modelSemantic proximity Read ↗

Genetically engineered ERα-positive breast cancer mouse modelsSemantic proximity Read ↗

The EO771 mammary cancer cell line displays a luminal B phenotype and it is sensitive to anti-estrogen treatmentsSemantic proximity Read ↗

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancerSemantic proximity Read ↗

EO771, is it a well-characterized cell line for mouse mammary cancer model? Limit and uncertainty.Semantic proximity Read ↗

Experimental models of endocrine responsive breast cancer: strengths, limitations, and useSemantic proximity Read ↗

New generation breast cancer cell lines developed from patient-derived xenograftsSemantic proximity Read ↗

Comparative analysis of syngeneic mouse models of high-grade serous ovarian cancerSemantic proximity Read ↗

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Semantic proximity Read ↗

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapySemantic proximity Read ↗

Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts.Semantic proximity Read ↗

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.