Article

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> Estrogen receptor positive (ER + ) subtypes of mammary adenocarcinoma comprise 79% of all breast cancer diagnosis and 67% of all breast cancer mortality. The paucity of models of ER + mammary cancer that mimic human disease and response to treatment has limited critical preclinical study of mechanisms and new therapies for ER + breast cancer. The Stat1 knockout, 129S6/SvEvTac-Stat1 tm1Rds (...

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Literature Corpus work: b9df1195-2e3d-5839-a38e-d765a65016ef
DOI: 10.1101/2025.02.02.636128

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