Article
The translational landscape of human vascular smooth muscle cells identifies novel short open reading frame-encoded peptide regulators for phenotype alteration.
Cardiovascular research - 6 Jul 2023
Li Kang, Li Bin, Zhang Dihua, Du Tailai, Zhou Huimin, Dai Gang, Yan Youchen, Gao Nailin, Zhuang Xiaodong, Liao Xinxue, Liu Chen, Dong Yugang, Chen Demeng, Qu Liang-Hu, Ou Jingsong, Yang Jian-Hua, Huang Zhan-Peng
Abstract excerpt
AIMS: The plasticity of vascular smooth muscle cells (VSMCs) enables them to alter phenotypes under various physiological and pathological stimuli. The alteration of VSMC phenotype is a key step in vascular diseases, including atherosclerosis. Although the transcriptome shift during VSMC phenotype alteration has been intensively investigated, uncovering multiple key regulatory signalling pathways, the translatome...
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