Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis.

Abstract excerpt

In the healthy mature artery, vascular cells, including endothelial cells, smooth muscle cells (SMCs), and fibroblasts are organized in different layers, performing specific functions. SMCs located in the media are in a differentiated state and exhibit a contractile phenotype. However, in response to vascular injury within the intima, stimuli from activated endothelial cells and recruited inflammatory cells reach...

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• Atherosclerosis
• Cancer-related molecular mechanisms research
• Cell Plasticity
• Cell Transdifferentiation
• Muscle, Smooth, Vascular