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Article

Clinical features of de novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations.

Journal of hematology & oncology - 4 Oct 2014

Loghavi Sanam, Zuo Zhuang, Ravandi Farhad, Kantarjian Hagop M, Bueso-Ramos Carlos, Zhang Liping, Singh Rajesh R, Patel Keyur P, Medeiros L Jeffrey, Stingo Francesco, Routbort Mark, Cortes Jorge, Luthra Rajyalakshmi, Khoury Joseph D

Abstract excerpt

BACKGROUND: De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis of integrative genomic analysis, but the clinical features of such patients have not been characterized systematically. METHODS: We assessed the features of patients (n = 178) harboring mutations in DNMT3A, FLT3 and/or NPM1,...

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Source

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Identifiers

PMID: 25281355
DOI: 10.1186/s13045-014-0074-4
PMCID: PMC4197326

Genes

NPM1
FLT3
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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