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Article

Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations.

Oncotarget - 23 Aug 2016

Shin Sang-Yong, Lee Seung-Tae, Kim Hee-Jin, Cho Eun Hae, Kim Jong-Won, Park Silvia, Jung Chul Won, Kim Sun-Hee

Abstract excerpt

We selected 19 significantly-mutated genes in AMLs, including FLT3, DNMT3A, NPM1, TET2, RUNX1, CEBPA, WT1, IDH1, IDH2, NRAS, ASXL1, SETD2, PTPN11, TP53, KIT, JAK2, KRAS, BRAF and CBL, and performed massively parallel sequencing for 114 patients with acute myeloid leukemias, mainly including those with normal karyotypes (CN-AML). More than 80% of patients had at least one mutation in the genes tested. DNMT3A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27359055
DOI: 10.18632/oncotarget.10240
PMCID: PMC5342384

Genes

ASXL1
BRAF
CBL
ELN
FLT3
IDH1
IDH2
JAK2
KIT
KRAS
NPM1
NRAS
PTPN11
RUNX1
SETD2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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