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Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer

10 Mar 2023

Abstract excerpt

mRNA delivery has shown high application value in the treatment of various diseases, but its effective delivery is still a major challenge at present. Herein, we propose a lantern-shaped flexible RNA origami for mRNA delivery. The origami is composed of a target mRNA scaffold and only two customized RGD-modified circular RNA staples, which can compress the mRNA into nanoscale and facilitate its endocytosis by...

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PMID: 36894556
DOI: 10.1038/s41467-023-37020-y

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