Targeting dendritic cells with RNA-loaded nanoparticles grafted with short peptides

Abstract excerpt

Nanoparticles encapsulating therapeutic RNA have emerged as a transformative strategy in precision medicine, capable of mobilizing the immune system to induce specific responses, ranging from immune tolerance to fighting tumors. However, most current preclinical and clinical efforts rely on non-targeted delivery systems, limiting their safety, therapeutic efficacy, and selectivity. To enhance the therapeutic index...

Topics

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• Animal Virus Infections Studies
• CAR-T cell therapy research
• Immunotherapy and Immune Responses
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

b5274c52-be45-599f-a3fd-915dfa6354ee

DOI

10.1101/2025.11.05.686747