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From structural design to delivery: mRNA therapeutics for cancer immunotherapy

17 Nov 2023

Abstract excerpt

mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority in expressing all sequence-known proteins in vivo. In particular, with a small dosage of delivered mRNA, antigen-presenting cells (APCs) can synthesize mutant neo-antigens and multi-antigens and present epitopes to T lymphocytes to elicit antitumor effects. In addition, expressing receptors like chimeric...

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PMID: 38855617
DOI: 10.1002/exp.20210146

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