Article
Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs
2025-03-11
Abstract excerpt
Tools to induce the formation of protein-protein interactions (PPIs) via small molecules are essential for investigating and engineering biological systems. Here, we introduce a protease-based strategy for controlling the preservation of otherwise self-cleaving nanobodies. By inserting the Hepatitis C Virus NS3 cis-protease into the nanobody scaffold, we showed that the antigen-binding ability of these chimeric na...
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Identifiers and source
- Literature Corpus work
- 598f241f-257c-52d3-93c2-667daa06394c
- DOI
- 10.1101/2025.03.09.642226