Article

Oral Spatiotemporal Nanoassembly for Sequential Genetic Reprogramming from Gut to Periphery Organ

2026-01-27

Abstract excerpt

<title>Abstract</title> <p>Oral gene therapy for metabolic diseases necessitates physiologically aligned strategies to sequentially regulate the gut-organ axis. Nevertheless, the gastrointestinal environment and unpredictable biodistribution limit the efficiency of conventional gene delivery. Here, we develop Layer-by-Layer Chylomicron-Mimicking Self-Assembly (LbL-CMSA), which enables sequential gene reprogrammin...

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Identifiers and source

Literature Corpus work: 007234d4-a993-5458-b427-108df555ef14
DOI: 10.21203/rs.3.rs-8523305/v1

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