Correlation of Precisely Fabricated Geometric Characteristics of DNA-Origami Nanostructures with Their Cellular Entry in Human Lens Epithelial Cells

Abstract excerpt

<title>Abstract</title> <p>Human lens epithelial cells (<italic>h</italic>LECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to <italic>h</italic>LECs, especially to sub-cellular organelles (e.g., mitochondrion and nucleus), is a key step in engineering cells for cell- and gene- based therapies. Despite a broad variety o...

Topics

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• 3D Printing in Biomedical Research
• Advanced biosensing and bioanalysis techniques
• Cancer Cells and Metastasis
• Cell Adhesion Molecules Research
• China
• DNA, Viral
• RNA Interference and Gene Delivery
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

278c6aba-bc69-56da-a430-d18090ff4a5b

DOI

10.21203/rs.3.rs-4897446/v1