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Designer cellular spheroids with DNA origami for drug screening

19 Jul 2024

Abstract excerpt

Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate human tissues, they lack cellular intricacy, and integrating these models with high-throughput drug screening remains a challenge. Here, we introduce a method that uses self-assembling nucleic acid nanostructures decorated living cells, termed NACs, to create...

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PMID: 39028810
DOI: 10.1126/sciadv.ado9880

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