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Article

Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus.

Protein science : a publication of the Protein Society - 1 Apr 2023

Xu Wei-Feng, Sun Chen-Fan, Gao Wen-Li, Scharf Daniel H, Zhu Chen-Yang, Bu Qing-Ting, Zhao Qing-Wei, Li Yong-Quan

Abstract excerpt

The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A-factor regulatory cascade, stimulates the production of daptomycin by binding to the dptE promoter in Streptomyces roseosporus. Using pull-down assays, bacterial...

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Identifiers

PMID: 36882943
DOI: 10.1002/pro.4617
PMCID: PMC10031807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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