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Article

Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027.

BMC microbiology - 22 Jan 2009

Wang Lifei, Hu Yunfeng, Zhang Yanjuan, Wang Songmei, Cui Zhihui, Bao Yi, Jiang Wei, Hong Bin

Abstract excerpt

BACKGROUND: C-1027, produced by Streptomyces globisporus C-1027, is one of the most potent antitumoral agents. The biosynthetic gene cluster of C-1027, previously cloned and sequenced, contains at least three putative regulatory genes, i.e. sgcR1, sgcR2 and sgcR3. The predicted gene products of these genes share sequence similarities to StrR, regulators of AraC/XylS family and TylR. The purpose of this study was...

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Identifiers

PMID: 19159491
DOI: 10.1186/1471-2180-9-14
PMCID: PMC2657911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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