Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulation of daptomycin production by DepR2, an ArsR-family transcriptional factor.

Journal of industrial microbiology & biotechnology - 1 Dec 2017

Mao Xu-Ming, Luo Shuai, Li Yong-Quan

Abstract excerpt

Daptomycin, a lipopeptide antibiotic potently active against Gram-positive bacterial pathogens, is produced by Streptomyces roseosporus, but the transcriptional regulation on its biosynthesis is not fully understood. Here, we report that DepR2, an ArsR-family transcriptional regulator isolated previously by DNA-affinity purification, interacts directly with dptEp, the major promoter of the daptomycin gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins
Share to Daptomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Gene Expression Regulation, Bacterial

Share to Multigene Family

Share to Secondary Metabolism

Share to Streptomyces

Source

Identifiers

PMID: 29038911
DOI: 10.1007/s10295-017-1983-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulation of daptomycin production by DepR2, an ArsR-family transcriptional factor.PMID 29038911Read ↗

Transcriptional Regulator DasR Represses Daptomycin Production through Both Direct and Cascade Mechanisms in Streptomyces roseosporusSemantic proximity Read ↗

A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporusSemantic proximity Read ↗

Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus.Semantic proximity Read ↗

BldD, a master developmental repressor, activates antibiotic production in two Streptomyces speciesSemantic proximity Read ↗

Regulation of daptomycin biosynthesis in Streptomyces roseosporus : new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial productionSemantic proximity Read ↗

Regulatory and biosynthetic effects of the bkd gene clusters on the production of daptomycin and its analogs A21978C1-3.Semantic proximity Read ↗

Metabolic engineering of Streptomyces roseosporus for increased production of clinically important antibiotic daptomycinSemantic proximity Read ↗

Genome shuffling of Streptomyces roseosporus for improving daptomycin production.Semantic proximity Read ↗

A functional study of the global transcriptional regulator PadR from a strain Streptomyces fradiae-nitR+bld, resistant to nitrone-oligomycin.Semantic proximity Read ↗

Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor.Semantic proximity Read ↗

Structure-based functional analysis of a PadR transcription factor from Streptococcus pneumoniae and characteristic features in the PadR subfamily-2.Semantic proximity Read ↗

Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.