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Article

Regulatory and biosynthetic effects of the bkd gene clusters on the production of daptomycin and its analogs A21978C1-3.

Journal of industrial microbiology & biotechnology - 1 Apr 2018

Luo Shuai, Chen Xin-Ai, Mao Xu-Ming, Li Yong-Quan

Abstract excerpt

Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus in an acidic peptide complex A21978C. In this complex, A21978C1-3 is most abundant and contains branched-chain fatty acyl groups, while daptomycin has a straight decanoic acyl group. The branched-chain α-keto acid dehydrogenase complex (BCDH complex), encoded by bkd gene clusters in Streptomyces, is responsible for the early step...

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Share to 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Deoxyribonuclease I

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PMID: 29411202
DOI: 10.1007/s10295-018-2011-y

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