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Article

Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection.

Journal of applied microbiology - 1 Jun 2012

Wang L, Zhao Y, Liu Q, Huang Y, Hu C, Liao G

Abstract excerpt

AIMS: Daptomycin, one of the A21978C factors produced by Streptomyces roseosporus, is an acidic cyclic lipopeptide antibiotic with potent activity against a variety of Gram-positive pathogens. To increase the titre of this extensively used and clinically important antibiotic, we applied a reported-guided rpsL mutation selection system to generate strains producing high levels of A21978C. METHODS AND RESULTS: In...

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PMID: 22486967
DOI: 10.1111/j.1365-2672.2012.05302.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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