Article
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations.
Cells - 12 Dec 2022
Al-Maslamani Noor A, Oldershaw Rachel, Tew Simon, Curran Jude, D'Hooghe Pieter, Yamamoto Kazuhiro, Horn Henning F
Abstract excerpt
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The expansion process provides the benefit of generating a large number of cells required for implantation; however, during the expansion these cells de-differentiate and lose their chondrocyte phenotype. In this review we focus on...
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