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mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

3 Mar 2023

Abstract excerpt

Abstract Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical. Here we show that high expression of the immune checkpoint B7-H3 ( CD276 ) and high mTORC1 activity correlate with immunosuppressive phenotypes and worse clinical outcomes in 11,060 TCGA human tumors. We find that mTORC1 upregulates B7-H3 expression via...

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PMID: 36869048
DOI: 10.1038/s41467-023-36881-7

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