Back to search

Article

Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-Cancer

2022-08-16

Abstract excerpt

The immune checkpoint molecule CD70 and its receptor CD27 constitute the signal transduction axis, which is abnormally expressed in many solid tumors and is crucial for T cell co-stimulation and immune escape. Tumor cells regulate the expression of CD27 by expressing CD70 in tumor microenvironment and promote immune escape.The discovery of the immunosuppressive effect of the CD70-CD27 signaling axis on tumor cells...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
918173c9-b601-55ef-9e04-95b7c0361a47
DOI
10.21203/rs.3.rs-1949691/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-CancerDOI 10.21203/rs.3.rs-1949691/v1
A mechanistic, functional, and clinical perspective on targeting CD70 in cancerSemantic proximity
Multi-omics analyses of CD276 in pan-cancer reveals its clinical prognostic value in glioblastoma and other major cancer typesSemantic proximity
Transcriptome Analysis and Single-Cell Sequencing Analysis Reveal the Prognostic Value and Immune Landscapes of CD276 in Pan-Cancer and Clinical Validation in GlioblastomaSemantic proximity
Identification of CD73 as a Novel Biomarker Encompassing the Tumor Microenvironment, Prognosis, and Therapeutic Responses in Various CancersSemantic proximity
CD73/NT5E is a Potential Biomarker for Cancer Prognosis and Immunotherapy for Multiple Types of CancersSemantic proximity
Immunological Classification of Tumor Types and Advances in Precision Combination Immunotherapy.Semantic proximity
Regulation of cancer immune escape: The roles of miRNAs in immune checkpoint proteins.Semantic proximity
The bioinformatics and experimental analysis of CD276 for prognosis and immune infiltrates in colon adenocarcinomaSemantic proximity
Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)Semantic proximity
An EBNA1-YAP signaling axis drives immune escape through CD276 in EBV-associated gastric cancerSemantic proximity
The epiphany derived from T-cell–inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responsesSemantic proximity
Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapySemantic proximity
Select a neighboring publication to make it the new centre.