Article
TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy.
JCI insight - 8 Nov 2023
Patel Chirag H, Dong Yi, Koleini Navid, Wang Xiaoxu, Dunkerly-Eyring Brittany L, Wen Jiayu, Ranek Mark J, Bartle Laura M, Henderson Daniel B, Sagert Jason, Kass David A, Powell Jonathan D
Abstract excerpt
MTORC1 integrates signaling from the immune microenvironment to regulate T cell activation, differentiation, and function. TSC2 in the tuberous sclerosis complex tightly regulates mTORC1 activation. CD8+ T cells lacking TSC2 have constitutively enhanced mTORC1 activity and generate robust effector T cells; however, sustained mTORC1 activation prevents generation of long-lived memory CD8+ T cells. Here we show...
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