Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer's disease.

Alzheimer's research & therapy - 28 Feb 2023

Quan Meina, Wang Qi, Qin Wei, Wang Wei, Li Fangyu, Zhao Tan, Li Tingting, Qiu Qiongqiong, Cao Shuman, Wang Shiyuan, Wang Yan, Jin Hongmei, Zhou Aihong, Fang Jiliang, Jia Longfei, Jia Jianping

Abstract excerpt

BACKGROUND: Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer's disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit imaging markers in preclinical FAD. METHODS: One hundred thirty-nine asymptomatic subjects in FAD families, including 26 APOEε4 carriers, 17 APP and 20 PS1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Anisotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition

Share to Gyrus Cinguli

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36850008
DOI: 10.1186/s13195-023-01192-y
PMCID: PMC9972804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer's disease.PMID 36850008Read ↗

Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease.Semantic proximity Read ↗

The selective vulnerability of the left fimbria in cognitively normal APOE ε4 carriers: a localized structural correlate of high genetic risk for Alzheimer's disease.Semantic proximity Read ↗

The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults.Semantic proximity Read ↗

Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition.Semantic proximity Read ↗

Effects of apolipoprotein E4 genotype on cerebro-cerebellar connectivity, brain atrophy, and cognition in patients with Alzheimer's disease.Semantic proximity Read ↗

Linking Brain Imaging and Genomics in the Study of Alzheimer's Disease and AgingSemantic proximity Read ↗

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.Semantic proximity Read ↗

Different Hippocampus Functional Connectivity Patterns in Healthy Young Adults with Mutations of APP/Presenilin-1/2 and APOEε4.Semantic proximity Read ↗

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity Read ↗

Precuneus degeneration in nondemented elderly individuals with APOE ɛ4: Evidence from structural and functional MRI analyses.Semantic proximity Read ↗

Global dissection of the impact of Alzheimer’s disease on brain architecture and behavior: High resolution MRH resolves robust regional effectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.