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Article

Effects of apolipoprotein E4 genotype on cerebro-cerebellar connectivity, brain atrophy, and cognition in patients with Alzheimer's disease.

Journal of the neurological sciences - 15 Nov 2022

de Dieu Uwisengeyimana Jean, Wang Yaming, Nguchu Benedictor Alexander, Wang Xiaoxiao, Qiu Bensheng

Abstract excerpt

INTRODUCTION: While several studies have substantially revealed the influence of the apolipoprotein E4 genotype (APOE4) on the vulnerability of Alzheimer's disease (AD), there are still far fewer studies investigating whether and how APOE4, in the absence of the amyloid-β (Aβ), alters regional brain atrophy, cerebro-cerebellar connectivity and cognitive performance in AD patients. METHODS: We employed MRI and...

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Identifiers

PMID: 36201963
DOI: 10.1016/j.jns.2022.120435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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