Article
Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.
Human brain mapping - 1 Nov 2015
Ossenkoppele Rik, Cohn-Sheehy Brendan I, La Joie Renaud, Vogel Jacob W, Möller Christiane, Lehmann Manja, van Berckel Bart N M, Seeley William W, Pijnenburg Yolande A, Gorno-Tempini Maria L, Kramer Joel H, Barkhof Frederik, Rosen Howard J, van der Flier Wiesje M, Jagust William J, Miller Bruce L, Scheltens Philip, Rabinovici Gil D
Abstract excerpt
Alzheimer's disease (AD) can present with distinct clinical variants. Identifying the earliest neurodegenerative changes associated with each variant has implications for early diagnosis, and for understanding the mechanisms that underlie regional vulnerability and disease progression in AD. We performed voxel-based morphometry to detect atrophy patterns in early clinical stages of four AD phenotypes: Posterior...
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