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A cross-tissue transcriptome association study identifies key genes in essential hypertension

10 Feb 2023

Abstract excerpt

Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative trait loci (eQTL) to provide a better approach to finding genes associated with complex traits. GWAS summary data (N = 450,584) for essential hypertension...

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PMID: 36845374
DOI: 10.3389/fgene.2023.1114174

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