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Article

The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent.

Scientific reports - 23 Feb 2023

Holm Bente, Barsuhn Stephan, Behrens Hans-Michael, Krüger Sandra, Röcken Christoph

Abstract excerpt

Gastric cancer (GC) is the fifth most common cancer in the world with a poor prognosis. Both RNF43 and LRP1B function as tumor suppressors in the Wnt signaling pathway and have been described to be frequently mutated in GC. In this study of a large and well characterized cohort of 446 GCs we explored the significance of expression of RNF43 and LRP1B and their correlations with clinicopathological patient...

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Identifiers

PMID: 36823311
DOI: 10.1038/s41598-023-30294-8
PMCID: PMC9950470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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