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Article

Dysregulated Wnt signalling and recurrent mutations of the tumour suppressor RNF43 in early gastric carcinogenesis.

The Journal of pathology - 1 Nov 2016

Min Byung-Hoon, Hwang Jinha, Kim Nayoung Kd, Park Gibeom, Kang So Young, Ahn Sangjeong, Ahn Soomin, Ha Sang Yun, Lee Yun Kyung, Kushima Ryoji, Van Vrancken Michael, Kim Min Jung, Park Changho, Park Ha Young, Chae Jeesoo, Jang Se Song, Kim Sung Jin, Kim Young-Ho, Kim Jong-Il, Kim Kyoung-Mee

Abstract excerpt

Several recurrent mutations and epigenetic changes have been identified in advanced gastric cancer, but the genetic alterations associated with early gastric carcinogenesis and malignant transformation remain unclear. We investigated the genomic and transcriptomic landscape of adenomas with low-grade dysplasia (LGD) and high-grade dysplasia (HGD), and intestinal-type early gastric cancer (EGC). The results were...

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Source

Identifiers

PMID: 27514024
DOI: 10.1002/path.4777

Genes

RNF43
HGD
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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