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Article

Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response

11 Nov 2020

Abstract excerpt

Background & Aims RING finger protein 43 (RNF43) is a tumor suppressor that frequently is mutated in gastric tumors. The link between RNF43 and modulation of Wingless-related integration site (WNT) signaling has not been shown clearly in the stomach. Because mutations in RNF43 are highly enriched in microsatellite-unstable gastric tumors, which show defects in DNA damage response (DDR), we investigated whether...

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Share to Epigenetics and DNA Methylation
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 33188943
DOI: 10.1016/j.jcmgh.2020.11.005

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