Article
Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer.
Scientific reports - 30 Jul 2022
Siraj Abdul Khalid, Bu Rong, Masoodi Tariq, Parvathareddy Sandeep Kumar, Iqbal Kaleem, Al-Haqawi Wael, Al-Dossari Hassan, Azam Saud, Qadri Zeeshan, Annaiyappanaidu Padmanaban, Al-Dayel Fouad, Al-Kuraya Khawla Sami
Abstract excerpt
Mutation-induced activation of Wnt-β Catenin signaling pathway is frequent in CRC. The E3 ubiquitin ligase, RNF43, has been reported to negatively regulate the Wnt signaling pathway and RNF43 mutations are frequently seen in CRC. However, its role in Middle Eastern CRC remains unclear. Therefore, we employed Exome and Sanger sequencing technology to assess the frequency of RNF43 mutations and its association with...
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