Article
RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer.
Oncology reports - 1 Jun 2020
Matsumoto Akio, Shimada Yoshifumi, Nakano Mae, Oyanagi Hidehito, Tajima Yosuke, Nakano Masato, Kameyama Hitoshi, Hirose Yuki, Ichikawa Hiroshi, Nagahashi Masayuki, Nogami Hitoshi, Maruyama Satoshi, Takii Yasumasa, Ling Yiwei, Okuda Shujiro, Wakai Toshifumi
Abstract excerpt
Right-sided colorectal cancer (RCRC) demonstrates worse survival outcome compared with left-sided CRC (LCRC). Recently, the importance of RNF43 mutation and BRAF V600E mutation has been reported in the serrated neoplasia pathway, which is one of the precancerous lesions in RCRC. It was hypothesized that the clinical significance of RNF43 mutation differs according to primary tumor sidedness. To test this...
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