Article
Inhibition of ERAP1 represses HLA-B27 free heavy chains expression on polarized macrophages and interrupts NK cells activation and function from ankylosing spondylitis.
Clinical immunology (Orlando, Fla.) - 1 Mar 2023
Babaie Farhad, Mohammadi Hamed, Salimi Sorayya, Ghanavatinegad Alireza, Abbasifard Mitra, Yousefi Mehdi, Hajaliloo Mehrzad, Khalili Younes, Zamanlou Sajjad, Safari Roghaiyeh, Hemmatzadeh Maryam, Rezaiemanesh Alireza, Salimi Reza, Baradaran Behzad, Babaloo Zohreh
Abstract excerpt
BACKGROUND: We aimed to assess if Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms might impress Human leukocyte antigen (HLA)-B27-free heavy chains (FHCs) expression on macrophages and eventually NK cell activation in Ankylosing spondylitis (AS). METHODS: Blood samples were obtained from 10 HLAB27+ patients with protective and 10 HLAB27+ patients with non-protective genotype. Monocytes were isolated...
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