Article
Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis.
Immunology letters - 1 Jan 2020
Babaie Farhad, Mohammadi Hamed, Hemmatzadeh Maryam, Ebrazeh Mehrdad, Torkamandi Shahram, Yousefi Mehdi, Hajaliloo Mehrzad, Rezaiemanesh Alireza, Salimi Sorayya, Salimi Reza, Safarzadeh Elham, Baradaran Behzad, Babaloo Zohreh
Abstract excerpt
BACKGROUND: Ankylosing spondylitis (AS) is a prototype of chronic inflammatory arthritis termed seronegative spondyloarthropathies that typically affects the joints. Among the non-Human leukocyte antigen (HLA) loci, the strongest association has been observed with Endoplasmic reticulum aminopeptidase 1 (ERAP1) gene single nucleotide polymorphisms (SNPs). Moreover, the effect of ERAP1 gene SNPs on the...
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