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Article

ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface.

Molecular immunology - 1 Jun 2016

Tran Tri M, Hong Sohee, Edwan Jehad H, Colbert Robert A

Abstract excerpt

OBJECTIVE: Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) variants contribute to the risk of ankylosing spondylitis in HLA-B27 positive individuals, implying a disease-related interaction between these gene products. The aim of this study was to determine whether reduced ERAP1 expression would alter the cell surface expression of HLA-B27 and the formation of aberrant disulfide-linked forms that have been...

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Share to Aminopeptidases
Share to Gene Knockdown Techniques
Share to HLA-B27 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunoprecipitation

Share to Minor Histocompatibility Antigens

Share to Spondylitis, Ankylosing

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Source

Open in PubMed Open full text

Identifiers

PMID: 27107845
DOI: 10.1016/j.molimm.2016.04.002
PMCID: PMC5425939

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface.PMID 27107845Read ↗

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